Description

Levosulpiride is the pharmacologically active levo-isomer of sulpiride, a substituted benzamide derivative. This compound is a selective dopamine D2 and D3 receptor antagonist with prokinetic and antiemetic properties, making it a critical active pharmaceutical ingredient (API). It is primarily utilized in the formulation of pharmaceutical products targeting gastrointestinal motility disorders and certain psychiatric conditions, serving the needs of global pharmaceutical manufacturers and research institutions.

Application

• Pharmaceutical API: Core active ingredient in prescription medications for functional dyspepsia, gastroparesis, and irritable bowel syndrome.
• Gastroprokinetic Agent: Used in formulations designed to enhance gastric emptying and upper gastrointestinal motility.
• Antiemetic Therapy: Incorporated into drugs for the prevention and treatment of nausea and vomiting.
• Neuropsychiatric Research: Serves as a reference standard and tool compound in studies of dopamine receptor pharmacology.
• Generic Drug Manufacturing: Essential for producing generic versions of levosulpiride-based medications for global markets.
• Veterinary Pharmaceuticals: Potential application in veterinary medicine for gastrointestinal disorders in animals.

Basic Information

Product Name	Levosulpiride
CAS No.	23672-07-3
Molecular Formula	C15H23N3O4S
Molecular Weight	341.42 g/mol
Synonyms	(-)-Sulpiride; (S)-(-)-Sulpiride; Levobren; LEVONEURAX; (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-sulfamoyl-o-anisamide; (S)-5-(Aminosulfonyl)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide; L-Sulpiride; (3S)-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-sulfamoyl-2-methoxybenzamide
EINECS	Contact for details

Quality Control

Our Levosulpiride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical use, with specifications aligning with major pharmacopoeial guidelines. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Specific Rotation	-62.0° to -68.0° (c=1 in DMF)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.