Description

Desoximetasone 21-Sulfate Sodium Salt is a chemically modified derivative of the potent corticosteroid desoximetasone, designed for enhanced solubility and stability in aqueous formulations. This high-purity intermediate is critical for the development and manufacturing of advanced topical and ophthalmic pharmaceutical products. It is primarily utilized by pharmaceutical R&D laboratories and production facilities focused on creating next-generation anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel corticosteroid APIs (Active Pharmaceutical Ingredients).
• Topical Formulation R&D: Used in the development of creams, ointments, and gels for treating psoriasis, eczema, and other dermatological conditions.
• Ophthalmic Solution Development: Serves as a precursor for formulating eye drops targeting inflammatory eye diseases.
• Analytical Reference Standard: Employed as a certified reference material (CRM) in quality control laboratories for HPLC, LC-MS, or NMR method development and validation.
• Metabolite Studies: Used in pharmacological research to study the metabolism and pharmacokinetics of desoximetasone.
• Process Chemistry: Integral in scaling up and optimizing synthetic routes for corticosteroid manufacturing under GMP conditions.

Basic Information

Product Name	Desoximetasone 21-Sulfate Sodium Salt
CAS No.	23638-54-2
Molecular Formula	C22H29FO8S • Na
Molecular Weight	503.51 g/mol
Synonyms	9α-Fluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(sodium sulfate); Desoxymethasone 21-Sulfate Sodium; Sodium Desoximetasone Sulfate; 11β,21-Dihydroxy-16α-methyl-9α-fluoropregna-1,4-diene-3,20-dione 21-(sodium sulfate); TOPICORT® (desoximetasone) Sulfate Derivative
EINECS	Contact for details

Quality Control

Our Desoximetasone 21-Sulfate Sodium Salt is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and stringent controls for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with relevant pharmacopeial guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.