Description

n-(α,α,α-Trifluoro-m-Tolyl)Isonicotinamidine is a specialized organic compound featuring a trifluoromethylphenyl group linked to an isonicotinamidine moiety. This molecular architecture makes it a valuable high-purity intermediate for the synthesis of advanced chemical entities, particularly in pharmaceutical research and development. It is primarily sought by R&D chemists and process development scientists working in agrochemical, pharmaceutical, and material science industries who require precise building blocks for novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, or insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Used in organometallic chemistry and catalysis research due to the coordinating potential of the amidine and pyridine nitrogen atoms.
• Material Science Precursor: Employed in the creation of specialty polymers, liquid crystals, or organic electronic materials where fluorine incorporation modifies physical properties.
• Chemical Biology Probe: Utilized in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects requiring this unique fluorinated structure.

Basic Information

Product Name	n-(α,α,α-Trifluoro-m-Tolyl)Isonicotinamidine
CAS No.	23565-12-0
Molecular Formula	C14H10F3N3
Molecular Weight	277.25 g/mol
Synonyms	N-[3-(Trifluoromethyl)phenyl]-4-pyridinecarboximidamide; 4-[[[3-(Trifluoromethyl)phenyl]amino]methylene]pyridine; Isonicotinamidine, N-[3-(trifluoromethyl)phenyl]-; N-(3-Trifluoromethylphenyl)isonicotinamidine; α,α,α-Trifluoro-m-tolyl isonicotinamidine; 3-Trifluoromethylphenyl isonicotinamidine; m-Trifluoromethylphenyl isonicotinamidine
EINECS	Contact for details

Quality Control

Every batch of n-(α,α,α-Trifluoro-m-Tolyl)Isonicotinamidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for research and process development. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.