Description

(R)-1-(2-Chloroacetyl)Pyrrolidine-2-Carboxylic Acid is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key precursor for the development of pharmaceutical compounds, particularly those targeting neurological and cardiovascular pathways. This product is essential for research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and complex molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of complex drug molecules, particularly for neurological and cardiovascular targets.
• Peptidomimetic Research: Used in the design and synthesis of peptidomimetics and constrained amino acid analogs for drug discovery.
• Asymmetric Synthesis: Serves as a versatile building block for constructing stereochemically defined compounds in medicinal chemistry.
• Protease Inhibitor Development: A key precursor in the research and production of protease inhibitors due to its pyrrolidine carboxylic acid scaffold.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects.

Basic Information

Item	Details
Product Name	(R)-1-(2-Chloroacetyl)Pyrrolidine-2-Carboxylic Acid
CAS No.	23500-11-0
Molecular Formula	C7H10ClNO3
Molecular Weight	191.61 g/mol
Synonyms	(R)-1-(Chloroacetyl)pyrrolidine-2-carboxylic acid; (R)-1-Chloroacetyl-2-pyrrolidinecarboxylic acid; (2R)-1-(2-Chloroacetyl)pyrrolidine-2-carboxylic acid; (R)-PCA; (R)-N-Chloroacetylproline; L-Proline, 1-(chloroacetyl)-, (R)-; (R)-N-(Chloroacetyl)proline
EINECS	Contact for details

Quality Control

Our (R)-1-(2-Chloroacetyl)Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Products undergo rigorous analytical testing, including chiral purity verification, to meet the stringent requirements of pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.