Description

Cyclopentyllithium is a highly reactive organolithium compound, widely recognized as a powerful nucleophile and base in synthetic organic chemistry. Its primary value lies in its ability to efficiently introduce the cyclopentyl group into a wide array of molecular frameworks, enabling the synthesis of complex intermediates. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise carbon-carbon bond formation. Cyclopentyllithium CAS NO 23473-12-3 is a cornerstone for constructing key structural motifs in active ingredient development.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for constructing cyclopentyl-containing active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides that incorporate the cyclopentyl ring for enhanced biological activity.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials.
• Asymmetric Catalysis Ligand Preparation: Serves as a building block for chiral ligands and catalysts used in stereoselective transformations.
• Cross-Coupling Reactions: Acts as a nucleophilic partner in palladium-catalyzed cross-couplings, such as Negishi or Kumada reactions.
• Nucleophilic Addition to Carbonyls: Used for the addition to ketones, aldehydes, and esters to form tertiary alcohols and related structures.
• Lithium-Halogen Exchange: Facilitates the generation of other organolithium species or functional group interconversions.
• Fine Chemical Production: Applied in the custom synthesis of specialty chemicals and complex organic molecules for various industrial applications.

Basic Information

Item	Detail
Product Name	Cyclopentyllithium
CAS No.	23473-12-3
Molecular Formula	C5H9Li
Molecular Weight	76.06 g/mol
Synonyms	Lithium, cyclopentyl-; Cyclopentyl lithium; Cyclopentyllithium; Lithium cyclopentyl; Cyclopentane, lithio-; CP-Li; Cyclopentyl lithium solution; Lithium cyclopentylide
EINECS	Contact for details

Quality Control

Our Cyclopentyllithium is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Typical quality assessment includes titration for active lithium content, NMR analysis for structural confirmation and purity, and GC analysis to monitor solvent composition and impurity profiles. We adhere to cGMP principles where applicable, and a comprehensive Certificate of Analysis (COA) detailing assay, appearance, and specific tests is provided with each shipment to guarantee it meets your precise research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties as a strong base/organic solvent, easily oxidized, and highly volatile compound, it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures between 2°C and 8°C. The storage area must be cool, dry, well-ventilated, and away from sources of ignition, moisture, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (NMR)	Conforms to structure
Assay (Titration)	0.5 M to 2.0 M in specified solvent (e.g., cyclohexane, diethyl ether)
Purity (NMR/GC)	≥ 95% (by NMR, relative to internal standard)
Solvent	As specified (Cyclohexane, Diethyl ether, etc.)
Color (APHA)	≤ 50

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.