Description

D-Propargylglycine is a non-proteinogenic amino acid featuring a propargyl side chain, which serves as a versatile chemical handle for bioorthogonal reactions like the copper-catalyzed azide-alkyne cycloaddition (CuAAC). This unique structure makes it a critical building block in chemical biology and pharmaceutical research for site-specific labeling and conjugation. It is essential for researchers and manufacturers in the fields of proteomics, drug discovery, and the development of antibody-drug conjugates (ADCs) who require high-purity, reliable intermediates.

Application

• Chemical Biology Probe Synthesis: Used to incorporate alkyne groups into peptides, proteins, and other biomolecules for subsequent labeling via click chemistry.
• Antibody-Drug Conjugate (ADC) Development: Serves as a key linker component, enabling the controlled attachment of cytotoxic payloads to monoclonal antibodies.
• Metabolic Pathway Studies: Acts as a mechanism-based inhibitor of enzymes like cystathionine γ-lyase, useful for studying transsulfuration pathways.
• Pharmaceutical Intermediate: Employed in the synthesis of more complex molecules targeting various therapeutic areas.
• Bioconjugation and Material Science: Facilitates the surface functionalization of nanoparticles, polymers, and other materials for diagnostic and therapeutic applications.
• Peptidomimetic Research: Incorporated into peptide analogs to modulate biological activity, stability, and physicochemical properties.

Basic Information

Product Name	D-Propargylglycine
CAS No.	23235-03-2
Molecular Formula	C5H7NO2
Molecular Weight	113.11 g/mol
Synonyms	(R)-2-Amino-4-pentynoic acid; D-2-Amino-4-pentynoic acid; (R)-2-Amino-pent-4-ynoic acid; D-Prop-2-ynylglycine; (R)-Propargylglycine; (2R)-2-Amino-4-pentynoic acid; D-4-Pentynoic acid, 2-amino-; (R)-Amino-4-pentynoic acid
EINECS	Contact for details

Quality Control

Our D-Propargylglycine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.