Description

N,n-Dimethyl-2-(Trimethylsilyl)Acetamide is a specialized organosilicon reagent featuring a reactive acetamide group protected by a trimethylsilyl moiety. This compound matters as a versatile building block and protecting group agent in advanced organic synthesis, particularly for sensitive intermediates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: Used as a key reagent in the preparation of active pharmaceutical ingredients (APIs), especially where moisture-sensitive steps are involved.
• Peptide and Amide Bond Formation: Acts as a coupling agent or protecting group for carboxylic acids and amines in peptide synthesis.
• Silicon-Mediated Organic Transformations: Serves as a silylating agent in various reactions, including the protection of hydroxyl groups or the formation of silyl enol ethers.
• Agrochemical Production: Employed in the synthesis of complex herbicide and pesticide molecules requiring selective functional group manipulation.
• Material Science Research: Utilized in the development of novel silicon-containing polymers and hybrid organic-inorganic materials.
• Laboratory Reagent: Functions as a specialized solvent or reagent for anhydrous reactions in research and development settings.

Basic Information

Product Name	N,n-Dimethyl-2-(Trimethylsilyl)Acetamide
CAS No.	23184-28-3
Molecular Formula	C7H17NOSi
Molecular Weight	159.30 g/mol
Synonyms	N,N-Dimethyl-2-(trimethylsilyl)acetamide; 2-(Trimethylsilyl)-N,N-dimethylacetamide; Acetamide, N,N-dimethyl-2-(trimethylsilyl)-; TMS-DMA; (Dimethylamino)[(trimethylsilyl)acetyl]methane; N,N-Dimethyl-α-(trimethylsilyl)acetamide; N,N-Dimethyltrimethylsilylacetamide
EINECS	Contact for details

Quality Control

Our N,n-Dimethyl-2-(Trimethylsilyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.