Description

Sodium (6R-Trans)-3-(Acetoxymethyl)-7-[[[3-(2-Chlorophenyl)-5-Methylisoxazol-4-Yl]Carbonyl]Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate is the sodium salt of a key intermediate in the synthesis of advanced cephalosporin antibiotics. This high-purity compound is critical for ensuring the efficacy and safety of the final active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of third and fourth-generation cephalosporin antibiotics.
• API Manufacturing: Used in the final chemical synthesis steps to produce the active pharmaceutical ingredient for injectable antibiotic formulations.
• Research & Development: Serves as a reference standard and starting material in medicinal chemistry for developing new antibacterial compounds with improved spectra.
• Process Chemistry: Employed in scale-up and optimization studies for efficient, GMP-compliant production of cephalosporin drugs.

Basic Information

Product Name	Sodium (6R-Trans)-3-(Acetoxymethyl)-7-[[[3-(2-Chlorophenyl)-5-Methylisoxazol-4-Yl]Carbonyl]Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate
CAS No.	23179-69-3
Molecular Formula	C22H19ClN3NaO7S
Molecular Weight	527.91 g/mol
Synonyms	(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-3-[(acetyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt; Cefotaxime Sodium EP Impurity C; Sodium 7β-[2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-(acetoxymethyl)-3-cephem-4-carboxylate (related intermediate); Cephalosporin C-3' acetate sodium salt derivative; 7-ACA derivative sodium salt; 3-Acetoxymethyl-7β-[2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido]ceph-3-em-4-carboxylic acid sodium salt (isomeric form).
EINECS	Contact for details

Quality Control

Our Sodium (6R-Trans)-3-(Acetoxymethyl)-7-[[[3-(2-Chlorophenyl)-5-Methylisoxazol-4-Yl]Carbonyl]Amino]-8-Oxo-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylate is manufactured under strict quality systems. Each batch is tested to meet stringent specifications for pharmaceutical intermediates, with a focus on purity and impurity profile control. Certificates of Analysis (COA) documenting identity, assay, and related substances are provided with every shipment to ensure traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.