Description

4-Hydroxy-2,2,6,6-Tetramethylpiperidine-4-Carbonitrile is a high-purity, sterically hindered nitrile derivative of the tetramethylpiperidine family. This compound serves as a versatile and critical chemical intermediate and precursor in advanced organic synthesis. It is primarily sought by the pharmaceutical and specialty chemical industries for the development of complex molecules, including light stabilizers, nitroxide spin labels, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block for synthesizing complex APIs and drug candidates, particularly those requiring hindered amine structures.
• Hindered Amine Light Stabilizer (HALS) Precursor: A crucial starting material in the production of high-performance light stabilizers for polymers, plastics, and coatings to prevent UV degradation.
• Nitroxide Spin Probe Synthesis: Used in the preparation of stable nitroxide radicals for Electron Paramagnetic Resonance (EPR) spectroscopy and spin labeling applications in biochemistry and material science.
• Organic Synthesis Reagent: Employed as a versatile intermediate in various organic transformations, including nucleophilic additions and cyclization reactions, due to its reactive nitrile and hydroxyl groups.
• Polymer Modification: Acts as a functional monomer or additive to introduce steric hindrance and stability into polymer chains.
• Agrochemical Intermediate: Used in the research and development of novel agrochemicals and plant growth regulators.

Basic Information

Product Name	4-Hydroxy-2,2,6,6-Tetramethylpiperidine-4-Carbonitrile
CAS No.	23037-20-9
Molecular Formula	C10H18N2O
Molecular Weight	182.26 g/mol
Synonyms	4-Cyano-2,2,6,6-tetramethyl-4-piperidinol; 4-Hydroxy-2,2,6,6-tetramethylpiperidine-4-carbonitrile; 4-Cyano-4-hydroxy-2,2,6,6-tetramethylpiperidine; 2,2,6,6-Tetramethyl-4-piperidinol-4-carbonitrile; 4-Hydroxy-TEMPO nitrile; 4-Cyano-TEMPOL; 4-Hydroxy-2,2,6,6-tetramethyl-4-piperidinecarbonitrile; 4-Piperidinol, 4-cyano-2,2,6,6-tetramethyl-
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-2,2,6,6-Tetramethylpiperidine-4-Carbonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for sensitive pharmaceutical and R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.