Description

Angiotensin I/II (3-8) is a bioactive peptide fragment derived from the angiotensinogen cascade, specifically representing the hexapeptide sequence (Val-Tyr-Ile-His-Pro-Phe). This compound is a critical research tool for studying the renin-angiotensin system (RAS), which regulates blood pressure and fluid balance. It is essential for biochemical research, pharmaceutical development, and diagnostic applications targeting cardiovascular and renal functions.

Application

• Biochemical Research: Used as a standard or substrate in enzymatic studies of angiotensin-converting enzyme (ACE) and other proteases within the RAS pathway.
• Pharmaceutical R&D: Serves as a key intermediate or reference compound in the development of novel antihypertensive drugs and ACE inhibitors.
• Diagnostic Reagent Manufacturing: Employed in the production of immunoassay kits and biosensors for measuring angiotensin peptide levels in clinical samples.
• Cell Signaling Studies: Applied in in vitro and ex vivo models to investigate receptor binding, signal transduction, and physiological effects of angiotensin fragments.
• Peptide Synthesis & Conjugation: Acts as a building block for synthesizing longer peptide chains or for conjugation in antibody-peptide complex studies.
• Academic & Clinical Research: Fundamental for university and hospital labs exploring cardiovascular diseases, hypertension, and metabolic disorders.

Basic Information

Product Name	Angiotensin I/II (3-8)
CAS No.	23025-68-5
Molecular Formula	C38H53N9O8
Molecular Weight	763.9 g/mol
Synonyms	Angiotensin (3-8); Angiotensin I (3-8); Angiotensin II (3-8); Hexapeptide (Val-Tyr-Ile-His-Pro-Phe); Val-Tyr-Ile-His-Pro-Phe; VYIHPF; RAS Peptide Fragment; ACE Substrate Peptide
EINECS	Contact for details

Quality Control

Our Angiotensin I/II (3-8) is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, peptide content, and solvent residues are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.