Description

2-Chloro-5-(Trifluoromethyl)Phenylacetonitrile is a versatile and high-value fluorinated aromatic nitrile building block. This compound is essential for the synthesis of advanced agrochemicals and pharmaceuticals due to its unique trifluoromethyl and chloro substituents, which impart desirable biological activity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key precursor in the synthesis of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Pharmaceutical Building Block: Used in medicinal chemistry for the development of active pharmaceutical ingredients (APIs), particularly in areas requiring fluorinated motifs for improved efficacy and pharmacokinetics.
• Liquid Crystal & OLED Material Synthesis: Serves as a starting material for creating fluorinated aromatic components used in electronic display technologies.
• Specialty Polymer Modification: Employed to introduce fluorinated phenyl units into polymer chains, enhancing material properties like chemical resistance and thermal stability.
• Cross-Coupling Reactions: The nitrile and halogen functionalities make it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems.
• Organic Synthesis Reagent: Used in heterocyclic chemistry to construct nitrogen-containing rings such as pyrazoles, triazoles, and pyrimidines.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)Phenylacetonitrile
CAS No.	22902-88-1
Molecular Formula	C9H5ClF3N
Molecular Weight	219.59 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-p-toluonitrile; (2-Chloro-5-(trifluoromethyl)phenyl)acetonitrile; 2-Chloro-5-(trifluoromethyl)benzyl cyanide; α-Chloro-α,α,α-trifluoro-m-toluonitrile; 2-Chloro-α,α,α-trifluoro-4-methylbenzonitrile; 2-Chloro-5-(trifluoromethyl)benzenecarbonitrile; 22902-88-1; 2-Chloro-α,α,α-trifluoro-p-tolunitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-(Trifluoromethyl)Phenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent quality suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.