Description

H-D-Trp-Obzl Hcl is a protected derivative of the essential amino acid tryptophan, specifically the D-enantiomer with a benzyl ester protecting group. This high-purity chiral building block is critical for the synthesis of complex peptides and peptidomimetics where stereochemical control is paramount. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic agents, and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the D-tryptophan residue into peptide sequences.
• Biochemical Research: Serves as a precursor for labeled compounds or probes in metabolic and enzymatic studies.
• Protecting Group Strategy: The benzyl ester (Obzl) group allows for orthogonal deprotection in multi-step synthetic routes.
• Asymmetric Synthesis: Employed in the construction of non-natural amino acids and complex organic molecules requiring specific chirality.

Basic Information

Product Name	H-D-Trp-Obzl Hcl
CAS No.	22839-16-3
Molecular Formula	C19H20N2O2 • HCl
Molecular Weight	344.84 g/mol (Free base: 308.38)
Synonyms	D-Tryptophan benzyl ester hydrochloride; (R)-2-Amino-3-(1H-indol-3-yl)propanoic acid benzyl ester hydrochloride; Benzyl D-tryptophanate hydrochloride; H-D-Trp-OBzl•HCl; Boc-D-Trp-OBzl (precursor related); Fmoc-D-Trp(Boc)-OH (related protected form); D-Trp-Obzl HCl
EINECS	Contact for details

Quality Control

Our H-D-Trp-Obzl Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical assay, and impurity profile. We adhere to cGMP guidelines for the production of advanced pharmaceutical intermediates, ensuring suitability for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.