Description

3-[3-[(3-Amino-2,4,6-Triiodo-Benzoyl)Amino]Phenyl]Propanoic Acid is a high-purity iodinated aromatic compound, serving as a critical intermediate in the synthesis of advanced X-ray contrast media. Its molecular structure, featuring a triiodinated benzene core linked to a propanoic acid chain, provides the essential radiopacity required for diagnostic imaging agents. This compound is primarily utilized by pharmaceutical R&D and manufacturing sectors focused on developing non-ionic, low-osmolar contrast agents for enhanced patient safety and diagnostic clarity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of iopamidol, iohexol, and other non-ionic iodinated contrast media.
• Contrast Agent Research: Used in the development and scale-up of novel X-ray and computed tomography (CT) contrast agents.
• Diagnostic Imaging: Integral to producing agents for angiography, urography, and myelography procedures.
• Chemical Synthesis: Serves as a precursor for further functionalization to create targeted molecular probes.
• GMP Manufacturing: Supplied for use in regulated active pharmaceutical ingredient (API) production under cGMP guidelines.

Basic Information

Product Name	3-[3-[(3-Amino-2,4,6-Triiodo-Benzoyl)Amino]Phenyl]Propanoic Acid
CAS No.	22708-47-0
Molecular Formula	C16H12I3N2O3
Molecular Weight	677.99 g/mol
Synonyms	5-Amino-2,4,6-triiodo-N-[3-(2-carboxyethyl)phenyl]benzamide; 3-[3-[(3-Amino-2,4,6-triiodobenzoyl)amino]phenyl]propionic Acid; Iopamidol Intermediate; Iohexol Intermediate; AD-01; AD 01; 5-Amino-2,4,6-triiodo-N-[3-(2-carboxyethyl)phenyl]-benzamide; Benzamide, 5-amino-2,4,6-triiodo-N-[3-(2-carboxyethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our 3-[3-[(3-Amino-2,4,6-Triiodo-Benzoyl)Amino]Phenyl]Propanoic Acid is manufactured under strict quality systems to meet the exacting standards of pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with ICH Q7 guidelines and can supply material suitable for use in GMP manufacturing processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.