Description

Doxepin n-Oxide CAS NO 22684-91-9 is a key pharmaceutical intermediate and metabolite of the tricyclic antidepressant doxepin. Its significance lies in its role in drug metabolism studies and as a reference standard for analytical and research purposes. This compound is essential for pharmaceutical R&D laboratories, quality control units, and academic institutions focused on neuropharmacology and analytical chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of doxepin and its metabolites in drug substance and finished product analysis.
• Metabolite Research: Critical for in-vitro and in-vivo studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of the parent drug doxepin.
• Analytical Method Development: Serves as a critical component in developing and validating HPLC, LC-MS, and GC-MS methods for impurity profiling and bioanalytical assays.
• Pharmacology Studies: Employed in research to understand the biological activity and potential effects of doxepin metabolites.
• Quality Control & Assurance: Used by pharmaceutical manufacturers to monitor process-related impurities and ensure batch-to-batch consistency of doxepin-based APIs and formulations.
• Academic & Clinical Research: Supports fundamental research in neurochemistry, psychiatry, and therapeutic drug monitoring (TDM).

Basic Information

Product Name	Doxepin n-Oxide
CAS No.	22684-91-9
Molecular Formula	C19H21NO2
Molecular Weight	295.38 g/mol
Synonyms	Doxepin N-Oxide; Doxepin Oxide; Doxepin Metabolite; NSC 324618; 3-(Dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine N-oxide; 11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenz[b,e]oxepin N-oxide
EINECS	Contact for details

Quality Control

Our Doxepin n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profile determination via HPLC and other pharmacopeial methods, to ensure it meets high-purity standards suitable for research and analytical applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.