Description

2-(Trifluoromethyl)Cyclopropanecarboxylic Acid is a high-value fluorinated cyclopropane derivative, serving as a critical chiral building block in advanced organic synthesis. Its unique structure, featuring a cyclopropane ring and a trifluoromethyl group, imparts significant metabolic stability and lipophilicity to target molecules, making it indispensable for modern pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex, bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors, antiviral agents, and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and advanced materials with unique surface properties and chemical resistance.
• Chemical Biology Probes: Utilized as a building block for creating molecular probes to study enzyme mechanisms and biological pathways.

Basic Information

Product Name	2-(Trifluoromethyl)Cyclopropanecarboxylic Acid
CAS No.	22581-33-5
Molecular Formula	C5H5F3O2
Molecular Weight	154.09 g/mol
Synonyms	2-(Trifluoromethyl)cyclopropanecarboxylic acid; 2-(Trifluoromethyl)cyclopropane-1-carboxylic acid; α-(Trifluoromethyl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 2-(trifluoromethyl)-; 1-Cyclopropanecarboxylic acid, 2-(trifluoromethyl)-; (1R,2S)-rel-2-(Trifluoromethyl)cyclopropanecarboxylic acid (for chiral forms); TFCA (abbreviation)
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Cyclopropanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high-purity standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids, organic solvents, strong bases, and oxidizing agents. The container must be kept tightly sealed due to the compound's sensitivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grades)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.