Description

Clodronate Disodium Salt is a high-purity bisphosphonate compound, recognized for its potent osteoclast-mediated bone resorption inhibition. This makes it a critical active pharmaceutical ingredient (API) for developing treatments for bone-related disorders such as osteoporosis and hypercalcemia of malignancy. It is also a vital research tool in immunology for studying macrophage depletion. Industries requiring this compound include pharmaceutical manufacturing, advanced biomedical research, and specialty chemical synthesis.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of injectable and oral medications for osteoporosis, Paget's disease, and bone metastasis management.
• Biomedical Research Reagent: Essential for in vitro and in vivo studies focusing on osteoclast biology, bone metabolism, and calcium homeostasis.
• Immunology Research: Used in liposomal formulations for the selective depletion of macrophages and other phagocytic cells in experimental models.
• Reference Standard: Serves as a high-purity calibrant and standard in analytical laboratories for quality control and method development.
• Precursor for Derivatives: Acts as a key starting material for the synthesis of novel bisphosphonate analogs and prodrugs.

Basic Information

Product Name	Clodronate Disodium Salt
CAS No.	22560-50-5
Molecular Formula	CCl2H2Na2O6P2
Molecular Weight	308.88 g/mol
Synonyms	Dichloromethylene Bisphosphonic Acid Disodium Salt; Clodronic Acid Disodium Salt; Sodium Clodronate; Clodronate Sodium; (Dichloromethylene)bisphosphonic Acid Disodium Salt; BM-06011; Loron; Ostac
EINECS	245-059-6

Quality Control

Our Clodronate Disodium Salt is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets stringent specifications for pharmaceutical and research use. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We can supply material compliant with relevant pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
pH (5% solution)	4.0 - 6.0
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.