Description

4,4-Difluoroheptanedioic Acid Diethyl Ester is a high-purity fluorinated diethyl ester building block. This compound is valued for its unique difluoromethylene group, which can significantly alter the physicochemical properties of target molecules, enhancing metabolic stability and lipophilicity. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced fluorinated pesticides and herbicides, where the fluorine atoms can improve biological activity and environmental persistence.
• Material Science: Serves as a monomer or precursor for specialty polymers and liquid crystals, imparting unique dielectric and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, condensations, and other transformations to introduce a difunctional, fluorinated chain into complex molecular architectures.
• Fluorine Chemistry Research: An essential reagent for academic and industrial R&D focused on exploring the effects of fluorination in medicinal and materials chemistry.

Basic Information

Product Name	4,4-Difluoroheptanedioic Acid Diethyl Ester
CAS No.	22515-16-8
Molecular Formula	C11H18F2O4
Molecular Weight	252.26 g/mol
Synonyms	Diethyl 4,4-Difluoroheptanedioate; 4,4-Difluoropimelic Acid Diethyl Ester; Diethyl 4,4-Difluoropimelate; Heptanedioic Acid, 4,4-Difluoro-, Diethyl Ester; 4,4-Difluoropimelic Acid Diethyl Ester; Diethyl 4,4-Difluoroheptanedioate; 4,4-Difluoroheptanedioic Acid Diethyl Ester; 22515-16-8
EINECS	Contact for details

Quality Control

Our 4,4-Difluoroheptanedioic Acid Diethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.