Description

Guanethidine n-Oxide is a high-purity chemical compound of significant interest in advanced research and development. This compound serves as a critical intermediate and reference standard in the synthesis and study of pharmaceutical agents, particularly those targeting the sympathetic nervous system. It is primarily utilized by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the creation of novel therapeutics and analytical method development.

Application

• Pharmaceutical Research Intermediate: A key building block in the synthesis of guanethidine derivatives and related adrenergic neuron-blocking agents for preclinical studies.
• Reference Standard: Used as an analytical standard in High-Performance Liquid Chromatography (HPLC) and mass spectrometry for quality control and method validation in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating the mechanisms of action, metabolism, and structure-activity relationships (SAR) of sympatholytic drugs.
• Fine Chemical Synthesis: Serves as a specialized intermediate for contract research organizations (CROs) and custom synthesis operations developing new chemical entities.
• Academic Research: Utilized in university and institutional laboratories for pharmacological and medicinal chemistry research projects.

Basic Information

Product Name	Guanethidine n-Oxide
CAS No.	22388-79-0
Molecular Formula	C₁₀H₂₂N₄O
Molecular Weight	214.31 g/mol
Synonyms	Guanethidine N-Oxide; Guanethidine Oxide; Guanethidine Mono-N-Oxide; 2-[2-(Azepan-1-yl)ethyl]guanidine 1-oxide; 1-(2-Guanidinoethyl)azepane 1-oxide; N-Oxide of Guanethidine; Guanethidine 1-Oxide
EINECS	Contact for details

Quality Control

Our Guanethidine n-Oxide is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the exacting standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.