Description

4'-(Difluoromethoxy)Acetanilide is a specialized organic intermediate featuring a difluoromethoxy group attached to an acetanilide core. This compound matters for its role as a key building block in the synthesis of advanced pharmaceutical agents and agrochemicals, where the introduction of fluorine atoms is crucial for enhancing metabolic stability and biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries engaged in creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides, where the difluoromethoxy moiety can improve efficacy and environmental profile.
• Fluorinated Building Block: Serves as a versatile reagent for introducing the difluoromethoxy (-OCF2H) functional group into more complex molecular architectures in medicinal chemistry.
• Research & Development: Employed in academic and industrial labs for exploring structure-activity relationships (SAR) in drug discovery programs.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for producing high-value, fluorinated specialty chemicals.

Basic Information

Product Name	4'-(Difluoromethoxy)Acetanilide
CAS No.	22236-11-9
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	N-(4-(Difluoromethoxy)phenyl)acetamide; 4-Acetamidophenyl difluoromethyl ether; 1-Acetamido-4-(difluoromethoxy)benzene; Acetamide, N-[4-(difluoromethoxy)phenyl]-; p-(Difluoromethoxy)acetanilide; 4-(Difluoromethoxy)phenylacetamide; DFMA
EINECS	Contact for details

Quality Control

Our 4'-(Difluoromethoxy)Acetanilide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of pharmaceutical and agrochemical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.