Description

3,5-Di(Trifluoromethyl)Benzamide is a high-value fluorinated aromatic building block characterized by its two electron-withdrawing trifluoromethyl groups. This compound is essential for synthesizing advanced materials and active pharmaceutical ingredients (APIs) where enhanced lipophilicity, metabolic stability, and specific electronic properties are required. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds with targeted functionalities.

Application

• Pharmaceutical Intermediate: A key synthon in the development of protease inhibitors, kinase inhibitors, and other small-molecule drugs, leveraging the CF3 groups to modulate bioavailability and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorinated moiety contributes to improved environmental stability and efficacy.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, particularly in cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to alter dielectric properties and surface characteristics.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3,5-Di(Trifluoromethyl)Benzamide
CAS No.	22227-26-5
Molecular Formula	C9H5F6NO
Molecular Weight	257.14 g/mol
Synonyms	3,5-Bis(trifluoromethyl)benzamide; Benzamide, 3,5-bis(trifluoromethyl)-; 3,5-Di(trifluoromethyl)benzoic acid amide; α,α,α,α',α',α'-Hexafluoro-3,5-xylylamide; 3,5-Bis(trifluoromethyl)benzenecarboxamide
EINECS	Contact for details

Quality Control

Our 3,5-Di(Trifluoromethyl)Benzamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent quality suitable for demanding synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.