Description

Thiothixene is a potent thioxanthene derivative belonging to the class of typical antipsychotic agents. It is a critical active pharmaceutical ingredient (API) valued for its dopamine receptor antagonism, primarily used in the management of psychotic disorders. This compound is essential for pharmaceutical manufacturers and research institutions developing neuroleptic medications. Thiothixene CAS NO 22189-31-7 is supplied with a focus on high purity and consistent quality to meet stringent pharmacopeial standards.

Application

• Pharmaceutical API: Primary use as the active ingredient in the formulation of antipsychotic medications for treating schizophrenia and other psychotic conditions.
• Neuropharmacology Research: A key reference standard and tool compound in preclinical studies investigating dopamine receptor pathways and antipsychotic mechanisms of action.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of branded thiothixene-based pharmaceuticals.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control testing, method development, and validation in analytical laboratories.
• Clinical Trial Material: Supply of GMP-grade material for use in clinical research and development of new therapeutic formulations.

Basic Information

Product Name	Thiothixene
CAS No.	22189-31-7
Molecular Formula	C23H29N3O2S2
Molecular Weight	443.63 g/mol
Synonyms	Thiothixene; Tiotixene; Navane; P-4657B; CI-715; (Z)-N,N-Dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide; (Z)-Thiothixene; trans-Thiothixene
EINECS	244-818-3

Quality Control

Our Thiothixene is manufactured and tested under a strict quality management system. Each batch is analyzed to ensure it meets high-purity standards, typically conforming to or exceeding relevant pharmacopeial monographs (e.g., USP, Ph. Eur.). Comprehensive testing includes identity, assay, impurity profile, and residual solvents. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any individual impurity ≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.