Description

L-Pyroglutamic Acid β-Naphthylamide is a specialized biochemical reagent, a derivative of pyroglutamic acid coupled with a β-naphthylamide moiety. This compound is valued for its role as a chromogenic substrate in enzymatic assays, particularly for detecting specific protease activity. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors who require high-purity substrates for biochemical analysis and quality control testing.

Application

• Enzymatic Substrate: Primarily used as a chromogenic substrate for the detection and quantification of specific proteases, such as pyroglutamyl peptidase.
• Biochemical Research: A critical reagent in enzyme kinetics studies, inhibitor screening, and pathway analysis within academic and industrial R&D laboratories.
• Diagnostic Kits: Incorporated into in-vitro diagnostic (IVD) kits and assays for clinical testing and medical research applications.
• Pharmaceutical Development: Employed in drug discovery and development processes for target validation and compound screening.
• Quality Control: Used in the quality assurance of biopharmaceuticals to monitor enzyme activity and process consistency.

Basic Information

Product Name	L-Pyroglutamic Acid β-Naphthylamide
CAS No.	22155-91-5
Molecular Formula	C₁₅H₁₄N₂O₃
Molecular Weight	270.28 g/mol
Synonyms	L-Pyroglutamyl-β-naphthylamide; 5-Oxo-L-proline β-naphthylamide; L-Pyroglutamic acid 2-naphthylamide; L-5-Oxoproline β-naphthylamide; N-(2-Naphthyl)-5-oxo-L-prolinamide; Substrate for Pyroglutamyl Peptidase; PG-βNA
EINECS	Contact for details

Quality Control

Our L-Pyroglutamic Acid β-Naphthylamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and diagnostic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a low-humidity environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.