Description

Naloxone 3-B-D-Glucuronide CAS NO 22135-79-1 is a major, pharmacologically inactive metabolite of the opioid antagonist naloxone. This compound is of critical importance in pharmaceutical research and development, particularly for pharmacokinetic and metabolic studies. It serves as a key reference standard for analytical laboratories in the pharmaceutical and forensic toxicology sectors. Researchers and quality control professionals rely on this high-purity standard to ensure accurate quantification and understanding of naloxone metabolism in biological matrices.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification of naloxone metabolites in bioanalytical studies.
• Metabolite Identification & Research: Essential for in-vitro and in-vivo metabolic pathway studies of naloxone, supporting drug development and safety assessments.
• Forensic & Clinical Toxicology: Used to calibrate analytical equipment (LC-MS/MS, HPLC) for accurate detection and confirmation of naloxone use in urine, blood, and plasma samples.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Enables precise measurement of metabolite formation rates and clearance, vital for modeling drug behavior.
• Quality Control & Method Validation: Critical for developing, validating, and ensuring the compliance of analytical methods in GLP/GMP environments.
• Impurity Profiling: Acts as a known impurity standard in the quality control of naloxone active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	Naloxone 3-B-D-Glucuronide
CAS No.	22135-79-1
Molecular Formula	C25H33NO10
Molecular Weight	507.53 g/mol
Synonyms	Naloxone 3-β-D-Glucuronide; Naloxone 3-Glucuronide; Naloxone-3-O-β-D-Glucuronide; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one 3-β-D-Glucuronide; Naloxone Glucuronide; Naloxone-3-β-D-Glucopyranosiduronic Acid; Naloxone Metabolite; (-)-Naloxone 3-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Naloxone 3-B-D-Glucuronide is manufactured under strict quality systems to ensure it meets the exacting requirements for use as an analytical reference standard. Each batch undergoes comprehensive testing, including identity confirmation, purity assay, and impurity profiling via advanced chromatographic and spectroscopic techniques. Certificates of Analysis (COA) with detailed batch-specific results are provided, supporting compliance in GLP and GMP regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.