Description

5-Oxo-1-[(p-Tolyl)Sulphonyl]-L-Proline is a high-purity, specialty organic compound belonging to the class of N-tosyl proline derivatives. This molecule serves as a critical chiral building block and protecting group intermediate in sophisticated organic synthesis. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the development of novel active pharmaceutical ingredients (APIs) and complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of peptide-based drugs and other therapeutic agents.
• Asymmetric Synthesis: Utilized as a catalyst or auxiliary in stereoselective reactions to control the formation of specific enantiomers.
• Amino Acid Protection: Acts as a protecting group for the proline residue during multi-step peptide synthesis, preventing unwanted side reactions.
• Biochemical Research: Employed in proteomics and enzymology studies to investigate enzyme inhibition and protein interactions.
• Fine Chemical Production: Serves as a precursor in the manufacture of advanced materials, agrochemicals, and specialty chemicals.

Basic Information

Product Name	5-Oxo-1-[(p-Tolyl)Sulphonyl]-L-Proline
CAS No.	21957-65-3
Molecular Formula	C13H15NO5S
Molecular Weight	297.33 g/mol
Synonyms	N-(p-Toluenesulfonyl)-5-oxo-L-proline; L-Proline, 5-oxo-1-[(4-methylphenyl)sulfonyl]-; 1-Tosyl-5-oxoproline; (S)-1-(4-Methylphenylsulfonyl)-5-oxopyrrolidine-2-carboxylic Acid; 5-Oxo-1-tosyl-L-proline; N-Tosyl-5-oxo-L-proline; 1-(p-Tolylsulfonyl)-5-oxo-L-proline; 21957-65-3
EINECS	Contact for details

Quality Control

Our 5-Oxo-1-[(p-Tolyl)Sulphonyl]-L-Proline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral assays, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.