Description

n-Tosyl-L-Alanine is a protected amino acid derivative where the amine group is shielded by a tosyl group, and the carboxylic acid remains free. This specific molecular architecture makes it a versatile chiral building block for the synthesis of peptides and other complex organic molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development processes.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce the alanine residue with a protected amine, allowing for selective chain elongation.
• Biochemical Research: Serves as a standard or reagent in studies involving enzyme substrates, metabolic pathways, and protein engineering.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct stereogenic centers.
• Protecting Group Chemistry: The tosyl group can be selectively removed under specific conditions, making it valuable for multi-step synthetic strategies.

Basic Information

Product Name	n-Tosyl-L-Alanine
CAS No.	21957-58-4
Molecular Formula	C10H13NO4S
Molecular Weight	243.28 g/mol
Synonyms	N-(p-Toluenesulfonyl)-L-alanine; L-Alanine, N-[(4-methylphenyl)sulfonyl]-; Tosyl-L-alanine; N-Tosylalanine; N-p-Tosyl-L-alanine; (2S)-2-[(4-Methylphenyl)sulfonylamino]propanoic acid; TOS-ALA-OH; Ts-L-Ala-OH
EINECS	244-665-8

Quality Control

Our n-Tosyl-L-Alanine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-20° to -24° (c=1 in methanol)
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.