Description

n-Boc-S-Trityl-L-Cysteine is a high-purity, dual-protected derivative of the amino acid L-cysteine, widely recognized under CAS NO 21947-98-8. This compound is a critical building block in the synthesis of complex peptides and bioconjugates, offering orthogonal protection for both the amine and thiol functional groups. It is an essential raw material for pharmaceutical R&D, particularly in the development of therapeutic peptides, protein engineering, and the creation of antibody-drug conjugates (ADCs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of cysteine residues with orthogonal protecting groups.
• Antibody-Drug Conjugate (ADC) Development: Used to create linker-payload constructs for site-specific conjugation via the free thiol after selective deprotection.
• Pharmaceutical Research: Serves as a crucial building block in the discovery and synthesis of novel peptide-based therapeutics and protease inhibitors.
• Bioconjugation Chemistry: Enables the site-specific modification of proteins, antibodies, and other biomolecules for diagnostic and therapeutic applications.
• Chemical Biology Probes: Utilized in the synthesis of activity-based probes and tools for studying enzyme function and protein-protein interactions.
• Custom Peptide Services: A fundamental reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	n-Boc-S-Trityl-L-Cysteine
CAS No.	21947-98-8
Molecular Formula	C27H29NO4S
Molecular Weight	463.59 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-S-trityl-L-cysteine; Boc-Cys(Trt)-OH; (S)-2-((tert-Butoxycarbonyl)amino)-3-(tritylthio)propanoic acid; N-Boc-S-Triphenylmethyl-L-cysteine; N-Boc-S-Trityl-L-cysteine; Boc-L-Cys(Trt)-OH; L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(triphenylmethyl)-
EINECS	Contact for details

Quality Control

Our n-Boc-S-Trityl-L-Cysteine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to relevant industry standards, and custom synthesis to meet specific pharmacopeial (e.g., USP) or customer specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.