Description

n-(Benzyloxycarbonyl)Glycine-n-Ethylamide is a protected glycine derivative, specifically a benzyloxycarbonyl (Cbz) carbamate, widely used as a key synthetic intermediate in organic and peptide chemistry. Its primary value lies in providing a versatile, orthogonal protecting group for the amino terminus, enabling controlled peptide chain elongation and complex molecular assembly. This high-purity building block is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors developing novel therapeutic peptides and bioactive compounds.

Application

• Pharmaceutical Intermediate: Critical building block in the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• Bioconjugation Chemistry: Used to introduce protected glycine linkers for the site-specific modification of proteins, antibodies, and other biomolecules.
• Combinatorial Chemistry: A valuable reagent in the generation of diverse chemical libraries for high-throughput screening and drug discovery.
• Organic Synthesis: Serves as a precursor for the preparation of more complex amino acid derivatives and heterocyclic compounds.
• Agrochemical Research: Employed in the development of novel peptide-based crop protection agents and bioactive molecules.
• Academic & R&D: A standard reagent in university and industrial research laboratories for methodological studies in synthetic organic chemistry.

Basic Information

Product Name	n-(Benzyloxycarbonyl)Glycine-n-Ethylamide
CAS No.	21855-73-2
Molecular Formula	C₁₂H₁₆N₂O₃
Molecular Weight	236.27 g/mol
Synonyms	N-Carbobenzoxyglycine Ethylamide; N-Cbz-Glycine Ethylamide; N-(Benzyloxycarbonyl)glycine Ethylamide; Glycine, N-[(phenylmethoxy)carbonyl]-, ethylamide; Z-Gly-NHEt; Cbz-Gly-NHEt; Benzyl N-(2-ethylamino-2-oxoethyl)carbamate; Nα-Cbz-glycine ethylamide
EINECS	Contact for details

Quality Control

Our n-(Benzyloxycarbonyl)Glycine-n-Ethylamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.