Description

Nα-Tosyl-D-α,β-Diaminopropionic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a tosyl-protected α-amino group and a free β-amino group. This chiral building block is critical for the synthesis of complex peptides and peptidomimetics, offering researchers precise control over stereochemistry and molecular architecture. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers developing novel therapeutic agents, diagnostic probes, and advanced biochemical tools.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs, enzyme inhibitors, and receptor antagonists.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a D-configured, side-chain functionalized amino acid residue.
• Bioconjugation & Probe Development: The free β-amino group serves as a handle for site-specific labeling, linker attachment, or conjugation with other molecules for creating targeted imaging agents or drug conjugates (ADCs).
• Chemical Biology Research: Employed in studying enzyme mechanisms, protein-protein interactions, and as a component of custom amino acid libraries for screening.
• Catalyst & Ligand Preparation: Can be utilized to synthesize chiral ligands or organocatalysts for asymmetric synthesis.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Nα-Tosyl-D-α,β-Diaminopropionic Acid
CAS No.	21753-19-5
Molecular Formula	C10H14N2O4S
Molecular Weight	258.29 g/mol
Synonyms	D-2,3-Diaminopropionic Acid Nα-Tosyl Derivative; (R)-2-((4-Methylphenyl)sulfonamido)-3-aminopropanoic Acid; Tosyl-D-Dap-OH; N-Tosyl-D-2,3-diaminopropionic Acid; p-Toluenesulfonyl-D-α,β-diaminopropionic Acid; D-α-Tosylamido-β-aminopropionic Acid; Nα-(4-Toluenesulfonyl)-D-2,3-diaminopropanoic Acid
EINECS	Contact for details

Quality Control

Our Nα-Tosyl-D-α,β-Diaminopropionic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.