Description

3-(Acetylmethylamino)-2,4,6-Triiodo-5-[(Methylamino)Carbonyl]Benzoic Acid is a high-purity, iodinated organic compound with the CAS registry number 21656-26-8. This specialized chemical is a critical intermediate in the synthesis of advanced X-ray contrast media, where its unique structure provides essential properties for medical imaging. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers focused on diagnostic agents.

Application

• Key Intermediate for X-Ray Contrast Media: Serves as a crucial building block in the synthesis of non-ionic, iodinated contrast agents used in computed tomography (CT) and angiography.
• Pharmaceutical Research & Development: Used in the discovery and development of new diagnostic imaging compounds to improve safety and efficacy profiles.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex, high-value molecules with specific iodine substitution patterns.
• Reference Standard: Acts as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	3-(Acetylmethylamino)-2,4,6-Triiodo-5-[(Methylamino)Carbonyl]Benzoic Acid
CAS No.	21656-26-8
Molecular Formula	C12H11I3N2O4
Molecular Weight	635.94 g/mol
Synonyms	5-Acetamido-2,4,6-triiodo-N-methylisophthalamic Acid; Iopamidol Intermediate; Iopamidol Related Compound; 5-[(Methylamino)carbonyl]-2,4,6-triiodo-3-[(N-methylacetamido)]benzoic Acid; 3-Acetamido-2,4,6-triiodo-5-(N-methylcarbamoyl)benzoic Acid; Iopamidol Impurity; Iopamidol API Intermediate; N-Methyl-2,4,6-triiodo-5-(methylcarbamoyl)-3-acetamidobenzoic Acid
EINECS	Contact for details

Quality Control

Our production of 3-(Acetylmethylamino)-2,4,6-Triiodo-5-[(Methylamino)Carbonyl]Benzoic Acid adheres to stringent quality systems suitable for pharmaceutical intermediates. Every batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided and can be tailored to meet specific pharmacopeial or customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.