Description

1-Chloromethyl-2,3,4,5-Tetrafluoro-Benzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the reactive chloromethyl group and the electron-withdrawing tetrafluoro substitution, which enables precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel active ingredients and high-performance polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug molecules, particularly those requiring fluorinated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the fluorine atoms improve lipophilicity and target binding.
• Liquid Crystal Materials: Serves as a building block for fluorinated mesogens used in display technologies.
• Polymer & Resin Modification: Employed to introduce fluorinated benzyl groups into polymers, enhancing chemical resistance, thermal stability, and surface properties.
• Organic Electronics: Intermediate in the production of charge-transport materials and semiconductors for OLEDs and photovoltaic cells.
• Cross-coupling Reactions: Useful substrate in palladium-catalyzed reactions like Suzuki-Miyaura couplings for creating biaryl structures.

Basic Information

Product Name	1-Chloromethyl-2,3,4,5-Tetrafluoro-Benzene
CAS No.	21622-18-4
Molecular Formula	C7H3ClF4
Molecular Weight	198.55 g/mol
Synonyms	2,3,4,5-Tetrafluorobenzyl Chloride; α-Chloro-2,3,4,5-tetrafluorotoluene; (2,3,4,5-Tetrafluorophenyl)methyl Chloride; Benzene, 1-(chloromethyl)-2,3,4,5-tetrafluoro-; 2,3,4,5-Tetrafluorobenzylchloride; Tetrafluorobenzyl Chloride; TFB-Cl
EINECS	Contact for details

Quality Control

Our 1-Chloromethyl-2,3,4,5-Tetrafluoro-Benzene is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and sources of ignition. Due to the reactive chloromethyl group, it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.