Description

1-Ethynyl-2,3,4,5-Tetrafluoro-Benzene is a highly fluorinated aromatic building block containing a reactive ethynyl group. This compound is valued for its unique combination of aromatic stability, fluorine's electronic effects, and the versatile reactivity of the terminal alkyne, making it a critical intermediate in advanced synthesis. It is primarily sought by R&D and production chemists in the pharmaceutical, agrochemical, and materials science industries for constructing complex fluorinated molecules.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), where fluorine atoms can enhance metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides, leveraging fluorine's ability to improve lipophilicity and environmental persistence.
• Materials Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Click Chemistry: The terminal alkyne group readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer functionalization.
• Organic Synthesis Building Block: Employed in Sonogashira couplings and other cross-coupling reactions to introduce fluorinated arylacetylene units into complex molecular architectures.
• Research & Development: Essential for academic and industrial research exploring the properties and applications of perfluorinated aromatic systems.

Basic Information

Product Name	1-Ethynyl-2,3,4,5-Tetrafluoro-Benzene
CAS No.	21622-12-8
Molecular Formula	C8H2F4
Molecular Weight	174.10 g/mol
Synonyms	2,3,4,5-Tetrafluoroethynylbenzene; Ethynyltetrafluorobenzene; Tetrafluoroethynylbenzene; 1-Ethynyl-2,3,4,5-tetrafluorobenzene; Perfluoroethynylbenzene (common name); Benzene, 1-ethynyl-2,3,4,5-tetrafluoro-; TFE-B
EINECS	Contact for details

Quality Control

Our 1-Ethynyl-2,3,4,5-Tetrafluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed and stored upright. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.