Description

Z-Ala-Gln-Oh is a protected dipeptide derivative, specifically the Z-protected form of alanyl-glutamine. This compound is a crucial building block in peptide synthesis, offering a strategic combination of side-chain protection and a free C-terminal carboxylic acid for controlled chain elongation. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic peptides and biochemical research. The product is supplied under the CAS registry number 21467-17-4.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of complex peptide sequences in both research and GMP manufacturing.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing specific peptide fragments or smaller peptides.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Biochemical Research: Employed in studies of peptide structure-activity relationships (SAR), enzyme substrates, and receptor ligands.
• Custom Peptide Production: A fundamental component for CROs and CDMOs offering bespoke peptide synthesis services.
• Reference Standard: Can be used as a chromatographic or spectroscopic standard for quality control in peptide production.

Basic Information

Product Name	Z-Ala-Gln-Oh
CAS No.	21467-17-4
Molecular Formula	C16H21N3O6
Molecular Weight	351.36 g/mol
Synonyms	Nα-Carbobenzoxy-L-alanyl-L-glutamine; Z-L-Ala-L-Gln-OH; CBZ-Ala-Gln-OH; N-CBZ-L-alanyl-L-glutamine; Benzyloxycarbonyl-L-alanyl-L-glutamine; (2S)-2-[[(2S)-2-[(benzyloxy)carbonylamino]propanoyl]amino]-4-carbamoylbutanoic acid; Z-A-Q-OH; Z-Ala-Gln
EINECS	Contact for details

Quality Control

Our Z-Ala-Gln-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture uptake, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.