Description

((R)-5-Oxopyrrolidine-2-Carbonyl)-L-Alanine is a high-purity chiral building block and protected amino acid derivative of significant interest in advanced organic synthesis. Its core value lies in its role as a key intermediate for constructing complex peptides and peptidomimetics with precise stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and therapeutic peptides.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of peptide-based drugs and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce a protected proline-like residue with a carboxylic acid side chain.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new bioactive molecules.
• Chemical Biology Probes: Used to create labeled peptides and probes for studying enzyme mechanisms and protein interactions.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	((R)-5-Oxopyrrolidine-2-Carbonyl)-L-Alanine
CAS No.	21282-15-5
Molecular Formula	C8H12N2O4
Molecular Weight	200.19 g/mol
Synonyms	N-[(R)-5-Oxo-2-pyrrolidinylcarbonyl]-L-alanine; L-Alanine, N-[(5R)-5-oxo-2-pyrrolidinylcarbonyl]-; (R)-5-Oxo-L-prolyl-L-alanine; (R)-5-Oxoprolyl-L-alanine; N-(5-Oxo-D-prolyl)-L-alanine; N-[(R)-5-Oxoprolyl]-L-alanine; (R)-Pyroglutamyl-L-alanine; A key intermediate for peptide synthesis
EINECS	Contact for details

Quality Control

Our ((R)-5-Oxopyrrolidine-2-Carbonyl)-L-Alanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including chiral purity verification by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.