Description

(Trimethylsilyl)(Diphenylphosphino)Acetylene is a highly versatile organosilicon and organophosphorus hybrid reagent, featuring both a silyl-protected alkyne and a phosphine group. This unique bifunctional structure makes it a critical building block for constructing complex molecular architectures in advanced synthetic chemistry. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for ligand synthesis and cross-coupling reactions.

Application

• Ligand Precursor in Catalysis: Serves as a key starting material for synthesizing sophisticated phosphine-based ligands used in palladium, rhodium, and other transition metal-catalyzed reactions, including cross-couplings and hydrogenations.
• Pharmaceutical Intermediate: Employed in the research and development of active pharmaceutical ingredients (APIs), particularly for introducing acetylene and phosphine functionalities into complex molecules.
• Agrochemical Synthesis: Used in creating novel crop protection agents where the phosphine moiety can act as a ligand for catalysts or as part of the active ingredient's structure.
• Materials Science Research: Applied in the development of novel organic electronic materials, metal-organic frameworks (MOFs), and polymers where conjugated systems and metal coordination are important.
• Organometallic Chemistry: Acts as a versatile reagent for the preparation of metal complexes and clusters due to its ability to bind to metals via both phosphorus and the alkyne unit.
• Academic & Industrial R&D: A valuable tool for methodology development in synthetic organic chemistry, enabling new bond-forming strategies.

Basic Information

Product Name	(Trimethylsilyl)(Diphenylphosphino)Acetylene
CAS No.	21037-91-2
Molecular Formula	C₁₉H₂₁PSi
Molecular Weight	308.44 g/mol
Synonyms	Diphenyl(2-trimethylsilylethynyl)phosphine; (Diphenylphosphino)(trimethylsilyl)acetylene; Ethynyltrimethylsilane, (diphenylphosphino)-; 2-(Diphenylphosphino)ethynyltrimethylsilane; TMS-DPPA; (Trimethylsilyl)ethynyl-diphenylphosphine; Acetylene, (diphenylphosphino)trimethylsilyl-; (Diphenylphosphino)(trimethylsilyl)ethyne
EINECS	Contact for details

Quality Control

Our (Trimethylsilyl)(Diphenylphosphino)Acetylene is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced spectroscopic and chromatographic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C or as specified on the label. This compound is easily oxidized and moisture-sensitive; ensure containers are sealed properly after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
¹H NMR	Conforms to structure
³¹P NMR	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.