Description

Z-Ala-Pro-Oh is a protected dipeptide derivative, specifically the benzyloxycarbonyl (Z) protected form of alanyl-proline. This compound is a crucial building block in peptide synthesis, offering a strategic combination of a protected N-terminus and a free C-terminal carboxylic acid for controlled chain elongation. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers involved in the development of therapeutic peptides, protease inhibitors, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of longer peptide sequences in both research and GMP manufacturing.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for producing custom peptides and peptide mimetics.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various diseases.
• Biochemical Research: Employed in the study of enzyme-substrate interactions, particularly with proteases like dipeptidyl peptidase IV (DPP-4).
• Protease Inhibitor Development: Acts as a core scaffold or intermediate for designing and synthesizing novel inhibitors for proline-specific enzymes.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for peptide-related products.

Basic Information

Product Name	Z-Ala-Pro-Oh
CAS No.	21027-01-0
Molecular Formula	C16H20N2O5
Molecular Weight	320.34 g/mol
Synonyms	N-Cbz-L-Alanyl-L-Proline; N-Carbobenzoxy-L-alanyl-L-proline; Z-L-Ala-L-Pro-OH; Cbz-Ala-Pro-OH; Benzyloxycarbonyl-L-alanyl-L-proline; Nα-Carbobenzyloxy-L-alanyl-L-proline; (S)-2-(((Benzyloxy)carbonyl)amino)propanoic acid; L-Alanine, N-[(phenylmethoxy)carbonyl]-, L-prolyl-
EINECS	Contact for details

Quality Control

Our Z-Ala-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. A detailed Certificate of Analysis (COA) documenting all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	-70° to -80° (c=1 in DMF)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.