Description

H-Pro-p-Nitrobenzyl Ester Hbr is a protected amino acid derivative, specifically the hydrobromide salt of the p-nitrobenzyl ester of L-proline. This compound serves as a crucial building block in peptide synthesis, where the p-nitrobenzyl protecting group offers orthogonal deprotection strategies under mild conditions. It is primarily utilized by pharmaceutical research and development teams, as well as fine chemical manufacturers, for the production of novel peptide-based therapeutics and bioactive compounds.

Application

• Peptide Synthesis Intermediate: A key protected amino acid for solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Research: Used in the R&D of peptide drugs, hormones, and enzyme inhibitors.
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for drug discovery screening.
• Bioconjugation: Acts as a precursor for creating peptide-protein or peptide-small molecule conjugates.
• Fine Chemical Production: Serves as a specialized intermediate in the multi-step synthesis of complex organic molecules.

Basic Information

Product Name	H-Pro-p-Nitrobenzyl Ester Hbr
CAS No.	20994-74-5
Molecular Formula	C13H16N2O4 • HBr
Molecular Weight	361.19 g/mol
Synonyms	L-Proline, 1-(4-nitrobenzyl) ester, hydrobromide; (S)-1-((4-Nitrobenzyl)oxy)-1-oxopyrrolidine-2-carboxylic acid hydrobromide; H-Pro-ONbzl.HBr; Fmoc-Pro-ONbzl precursor; p-Nitrobenzyl L-prolinate hydrobromide; Proline p-nitrobenzyl ester HBr; Boc-Pro-ONbzl hydrobromide salt
EINECS	Contact for details

Quality Control

Our H-Pro-p-Nitrobenzyl Ester Hbr is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and synthesis applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, chiral purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP environments for non-API intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.