Description

2-Fluoro-1-Methoxy-4-(Methylsulfonyl)Benzene is a high-purity, multi-functional aromatic building block of significant interest in advanced organic synthesis. Its unique molecular architecture, featuring fluorine, methoxy, and methylsulfonyl substituents, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity-modifying effects of the fluorine and sulfone groups.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing sulfone moiety.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to introduce functionalized aryl groups.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development, quality control, and regulatory submissions in API manufacturing.

Basic Information

Product Name	2-Fluoro-1-Methoxy-4-(Methylsulfonyl)Benzene
CAS No.	20951-14-8
Molecular Formula	C8H9FO3S
Molecular Weight	204.22 g/mol
Synonyms	1-Fluoro-2-Methoxy-5-(Methylsulfonyl)Benzene; 4-Fluoro-3-Methoxy Phenyl Methyl Sulfone; 2-Fluoroanisole-4-methylsulfone; 4-(Methylsulfonyl)-2-fluoroanisole; 5-Fluoro-2-methoxy-1-methylsulfonylbenzene; 2-Fluoro-4-(methylsulfonyl)anisole; 1-Methoxy-2-fluoro-4-(methylsulfonyl)benzene
EINECS	Contact for details

Quality Control

Our 2-Fluoro-1-Methoxy-4-(Methylsulfonyl)Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.