Description

Angiotensinogen is a critical plasma protein and the sole precursor to the potent vasoconstrictor peptides of the renin-angiotensin system (RAS). Its precise quantification and purity are essential for research into cardiovascular physiology, hypertension, and renal function. This high-purity biochemical is primarily utilized by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic research institutions focused on endocrinology and cardiovascular disease mechanisms.

Application

• Biomedical Research: Fundamental studies on the renin-angiotensin system (RAS), blood pressure regulation, and fluid homeostasis.
• Diagnostic Development: Calibration standard and key component in immunoassays (ELISA, RIA) for measuring plasma renin activity or angiotensinogen levels.
• Drug Discovery & Screening: Target substrate for high-throughput screening of novel renin inhibitors and modulators of the RAS pathway for antihypertensive therapies.
• Enzyme Kinetics: Substrate for kinetic studies of renin enzyme activity and inhibition constants.
• Reference Standard: Certified reference material for quality control in pharmaceutical manufacturing and clinical laboratory testing.
• Cell Culture & In Vitro Studies: Used in cell-based assays to study angiotensin peptide generation and receptor signaling pathways.

Basic Information

Item	Detail
Product Name	Angiotensinogen
CAS No.	20845-02-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Serpin A8; Angiotensin Precursor; Renin Substrate; ANGT; Serpin Peptidase Inhibitor Clade A Member 8; Pre-angiotensinogen; α-1 Antiproteinase
EINECS	Contact for details

Quality Control

Our Angiotensinogen is produced and tested under stringent quality management systems to ensure batch-to-batch consistency and reliability for critical research and diagnostic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological activity. We adhere to relevant guidelines for research-grade biochemicals to support your compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This material is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake. For extended storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Biological Activity	Determined by renin cleavage assay
Protein Content (Biuret)	≥ 90%
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.