Description

N-(Triphenylmethyl)formamide is a specialized organic compound featuring a formamide group protected by a bulky trityl (triphenylmethyl) moiety. This structure makes it a valuable protecting group reagent and a key synthetic intermediate in advanced organic synthesis, particularly for sensitive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of complex APIs, nucleotides, and peptides where selective protection strategies are required.

Application

• Amino Group Protection in Peptide Synthesis: The trityl group is widely used for the temporary protection of primary amines, especially in solid-phase peptide synthesis (SPPS).
• Intermediate for Nucleoside and Nucleotide Chemistry: Serves as a precursor or protecting reagent in the synthesis of modified nucleosides and oligonucleotides.
• Pharmaceutical Intermediate: Used in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Fine Chemical Synthesis: Acts as a building block for synthesizing specialty chemicals, catalysts, and ligands.
• Research & Development: Employed in academic and industrial R&D for developing new synthetic methodologies and novel compounds.
• Glycochemistry: Can be applied in the synthesis of glycosyl donors and acceptors where amine protection is necessary.

Basic Information

Product Name	N-(Triphenylmethyl)formamide
CAS No.	20799-66-0
Molecular Formula	C20H17NO
Molecular Weight	287.36 g/mol
Synonyms	Tritylformamide; N-Tritylformamide; N-Formyltriphenylmethylamine; Triphenylmethylformamide; Formamide, N-(triphenylmethyl)-; NSC 403058; Trt-NH-CHO
EINECS	Contact for details

Quality Control

Our N-(Triphenylmethyl)formamide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and specification compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.