Description

Codeine β-D-Glucuronide Triacetate Methyl Ester is a key chemical intermediate and reference standard derived from the metabolism of codeine. This compound is of significant importance for analytical research and pharmaceutical development, particularly in the study of drug metabolism and pharmacokinetics. It is primarily needed by research institutions, pharmaceutical manufacturers, and analytical laboratories involved in forensic toxicology, clinical research, and the development of controlled substance assays.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of codeine and its metabolites in various matrices.
• Metabolite Research: Serves as a critical standard in studies investigating the metabolic pathways, pharmacokinetics, and pharmacodynamics of codeine.
• Forensic Toxicology: Essential for the development and validation of analytical methods (e.g., LC-MS/MS, GC-MS) for detecting and quantifying opiate use in forensic and workplace drug testing.
• Clinical Trial Support: Utilized in bioanalytical laboratories to monitor drug levels and metabolic profiles during clinical trials involving opioid medications.
• Impurity Profiling: Acts as a specified impurity or degradation product standard in the quality control of codeine-based pharmaceutical products.
• Enzymatic Study Substrate: Can be used in biochemical assays to study the activity of glucuronosyltransferases and other metabolic enzymes.

Basic Information

Product Name	Codeine β-D-Glucuronide Triacetate Methyl Ester
CAS No.	20736-10-1
Molecular Formula	C₃₃H₃₉NO₁₃
Molecular Weight	657.66 g/mol
Synonyms	Codeine-6-β-D-glucuronide triacetate methyl ester; Morphine-3-β-D-glucuronide triacetate methyl ester (related structural analog); 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol β-D-glucopyranosiduronic acid triacetate methyl ester; Codeine glucuronide triacetate methyl ester; Methyl (2S,3S,4S,5R,6S)-3,4,5-triacetoxy-6-{[(1S,5R,13R,14S,17R)-14-hydroxy-3-methoxy-17-methyl-4,5-epoxymorphinan-6-yl]oxy}oxane-2-carboxylate; Codeine metabolite derivative; O6-β-D-Glucopyranuronosylcodeine triacetate methyl ester
EINECS	Contact for details

Quality Control

Our Codeine β-D-Glucuronide Triacetate Methyl Ester is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized using advanced spectroscopic and chromatographic techniques to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (typically ≥95% by HPLC), identification (IR, NMR), and impurity profiles are provided to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.