Description

3,3,3-Trifluoropropionitrile is a versatile fluorinated nitrile building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity of the nitrile group combined with the strong electron-withdrawing and lipophilicity-enhancing properties of the trifluoromethyl group. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to incorporate fluorine into complex molecules to modulate their biological activity, stability, and physical properties.

Application

• Pharmaceutical Intermediate: A key precursor for synthesizing trifluoromethyl-substituted heterocycles, such as pyrazoles and triazoles, which are common scaffolds in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the production of novel herbicides and pesticides, where the CF3 group enhances compound efficacy and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, improving charge transport and thermal stability.
• Fluorinated Polymer Monomer: Can be utilized to introduce fluorine into polymer backbones, granting materials enhanced chemical resistance and lower surface energy.
• Organic Synthesis Reagent: Employed in nucleophilic addition and cycloaddition reactions to construct complex, fluorinated molecular architectures.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and creating compound libraries for high-throughput screening.

Basic Information

Product Name	3,3,3-Trifluoropropionitrile
CAS No.	20530-38-5
Molecular Formula	C3H2F3N
Molecular Weight	109.05 g/mol
Synonyms	3,3,3-Trifluoropropanenitrile; 2,2,2-Trifluoroethyl cyanide; Trifluoropropiononitrile; β,β,β-Trifluoropropionitrile; Perfluoropropionitrile (incorrect but common alias); TFPN; TFPN; 20530-38-5 (CAS Registry Number)
EINECS	243-858-6

Quality Control

Our 3,3,3-Trifluoropropionitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.