Description

2-(1-Hydroxyethyl)Thiamine Pyrophosphate is a phosphorylated derivative of thiamine (vitamin B1) and a key intermediate in biological energy metabolism. This compound is of significant interest for research into enzymatic cofactors and metabolic pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical sectors for biochemical studies and high-purity synthesis.

Application

• Biochemical Research: Used as a reference standard and intermediate in studies of thiamine-dependent enzymes, such as pyruvate dehydrogenase and transketolase.
• Pharmaceutical Development: Serves as a critical precursor or intermediate in the synthesis of novel therapeutic agents targeting metabolic disorders.
• Enzymology Studies: Employed to investigate the mechanism of action and kinetics of enzymes that utilize thiamine pyrophosphate as a cofactor.
• Diagnostic Reagent Manufacturing: Used in the formulation of diagnostic kits and assays for clinical and research laboratories.
• Nutraceutical Research: Investigated for its potential role and bioavailability in advanced vitamin B1 formulations.
• Metabolic Pathway Analysis: A key tool in cellular and microbiological research to map and understand energy production pathways.

Basic Information

Product Name	2-(1-Hydroxyethyl)Thiamine Pyrophosphate
CAS No.	20319-27-1
Molecular Formula	C14H23N4O8P2S
Molecular Weight	461.36 g/mol
Synonyms	2-(1-Hydroxyethyl)thiamine diphosphate; 2-(α-Hydroxyethyl)thiamine pyrophosphate; HETPP; 2-(1-Hydroxyethyl)-thiamine diphosphate; Acetylhydroxyethylthiamine pyrophosphate; Hydroxyethylthiamine pyrophosphate; Thiamine pyrophosphate hydroxyethyl derivative
EINECS	Contact for details

Quality Control

Our 2-(1-Hydroxyethyl)Thiamine Pyrophosphate is produced under stringent conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.