Description

3-Oxo-Cyclobutanecarbonitrile is a versatile and high-purity chemical building block characterized by its reactive ketone and nitrile functional groups on a strained cyclobutane ring. This unique structure makes it a valuable synthon for the development of complex molecules in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel synthetic routes, particularly for the construction of constrained ring systems and heterocycles. Our supply ensures consistent quality and reliable availability for critical development and scale-up projects.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing fused or spiro-cyclic systems.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides where the cyclobutane scaffold imparts unique biological activity.
• Material Science: Serves as a monomer or cross-linking agent in the research of specialty polymers with tailored thermal and mechanical properties.
• Organic Synthesis Building Block: Employed in [3+2] cycloadditions, ring-expansion reactions, and as a precursor for amino-cyclobutanes and other functionalized derivatives.
• Ligand and Catalyst Development: Useful for constructing chelating ligands with specific geometry for catalysis research.

Basic Information

Product Name	3-Oxo-Cyclobutanecarbonitrile
CAS No.	20249-16-5
Molecular Formula	C5H5NO
Molecular Weight	95.10 g/mol
Synonyms	3-Oxocyclobutanecarbonitrile; Cyclobutanone-3-carbonitrile; 3-Cyanocyclobutanone; 1-Oxaspiro[2.2]pentane-4-carbonitrile; 3-Ketocyclobutanecarbonitrile; Oxetan-3-one, 3-cyano-; 3-Oxocyclobutyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Oxo-Cyclobutanecarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.