Description

Methiothepin Maleate is a high-purity chemical compound of significant interest in advanced research and development. This compound serves as a critical tool in neuropharmacological studies, particularly for investigating serotonin receptor systems. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and specialty chemical manufacturers focused on developing novel therapeutic agents.

Application

• Pharmacological Research: A key reference standard and tool compound for studying serotonin (5-HT) receptor antagonism, particularly at 5-HT1 and 5-HT2 receptor subtypes.
• Neuroscience Studies: Used in in vitro and ex vivo assays to elucidate the role of serotonergic pathways in various neurological functions and behaviors.
• Drug Discovery & Development: Serves as a chemical probe in high-throughput screening and target validation during the early stages of central nervous system (CNS) drug discovery programs.
• Reference Standard: Employed as an analytical standard in method development and quality control for related pharmaceutical ingredients and metabolites.
• Biochemical Assays: Utilized in receptor binding studies and functional assays to determine the potency and selectivity of new chemical entities.

Basic Information

Product Name	Methiothepin Maleate
CAS No.	20229-30-5
Molecular Formula	C₂₁H₂₆N₂O₂S₂ • C₄H₄O₄
Molecular Weight	534.64 g/mol
Synonyms	Methiothepin Maleate Salt; Methiothepin Maleate; Methiothepin hydrogen maleate; 10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl-1-piperazine maleate; 1-(10,11-Dihydro-8-(methylthio)dibenzo[b,f]thiepin-10-yl)-4-methylpiperazine maleate; Ro 8-6837/001; Methiothepin (as maleate)
EINECS	Contact for details

Quality Control

Our Methiothepin Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the stringent requirements of research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.