Description

L-Proline, 4-(Methylthio)-, cis- (9Ci) is a non-proteinogenic, sulfur-containing derivative of the amino acid L-proline. This specialized chiral building block is valued for its unique structural features, which enable the synthesis of complex molecules with specific stereochemistry and bioactivity. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for use as a key intermediate in drug discovery, peptide modification, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptidomimetic drug candidates.
• Peptide Chemistry: Used to introduce conformational constraints and modify the physicochemical properties of synthetic peptides, enhancing their stability and biological activity.
• Agrochemical Research: Serves as a building block in the synthesis of novel herbicides, fungicides, and plant growth regulators that leverage its sulfur moiety.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate metabolic pathways involving proline and sulfur metabolism.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or ligand in catalytic asymmetric reactions to induce enantioselectivity.
• Material Science: Investigated for the development of functionalized polymers and advanced materials with specific molecular recognition properties.

Basic Information

Item	Detail
Product Name	L-Proline, 4-(Methylthio)-, cis- (9Ci)
CAS No.	20182-95-0
Molecular Formula	C6H11NO2S
Molecular Weight	161.22 g/mol
Synonyms	(2S,4R)-4-(Methylthio)proline; cis-4-(Methylthio)-L-proline; (4R)-4-(Methylsulfanyl)-L-proline; 4-Methylmercaptoproline; L-4-(Methylthio)proline; 4-Methylthio-L-proline; 4-(Methylthio)proline; (2S,4R)-4-(Methylsulfanyl)pyrrolidine-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our L-Proline, 4-(Methylthio)-, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.