Description

6-Demethylgriseofulvin is a key intermediate and derivative of the antifungal agent griseofulvin, distinguished by its modified molecular structure. This compound is of significant interest in pharmaceutical research and development for the synthesis of novel antifungal agents and for structure-activity relationship (SAR) studies. It serves as a critical building block for researchers and manufacturers in the pharmaceutical and fine chemical sectors who require high-purity intermediates for advanced synthesis.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of griseofulvin analogs and novel antifungal compounds.
• Research & Development: Used in academic and industrial laboratories for pharmacological studies and structure-activity relationship (SAR) investigations.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Utilized in studies exploring the mechanism of action of griseofulvin and its derivatives on fungal cell mitosis.
• Fine Chemical Synthesis: Acts as a specialized building block for the preparation of more complex, biologically active molecules.

Basic Information

Product Name	6-Demethylgriseofulvin
CAS No.	20168-88-1
Molecular Formula	C16H16ClO6
Molecular Weight	348.75 g/mol
Synonyms	6-Desmethylgriseofulvin; 7-Chloro-4,6-dimethoxy-6'-methyl-3H,4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione; Griseofulvin Impurity; NSC 51046; Griseofulvin Derivative; De(methyl)griseofulvin
EINECS	Contact for details

Quality Control

Our 6-Demethylgriseofulvin is produced under a rigorous quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for research and synthesis. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.