Description

(1As,4E,6R,10S,10Ar)-6-Acetoxy-3,6,10,10A-Tetrahydro-5,9-Dimethyl-10,1A-(Epoxymethano)-2H-Oxireno[4,5]Cyclodeca[1,2-B]Furan-12-One is a complex, high-purity sesquiterpene lactone derivative characterized by its intricate polycyclic structure. This compound matters as a critical advanced intermediate for pharmaceutical research and fine chemical synthesis, offering a unique scaffold for developing novel bioactive molecules. It is primarily needed by R&D teams and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries working on new active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Natural Product Analog Synthesis: Used as a precursor for creating analogs of complex sesquiterpene lactones to study structure-activity relationships (SAR).
• Agrochemical Research: Employed in the development of new plant protection agents and bioactive agrochemicals due to its inherent biological activity.
• Chemical Biology Probe: Utilized as a molecular tool to investigate biological pathways and protein interactions in academic and industrial research settings.
• Fine Chemical Synthesis: Acts as a chiral starting material or intermediate for the production of high-value, complex specialty chemicals.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Item	Detail
Product Name	(1As,4E,6R,10S,10Ar)-6-Acetoxy-3,6,10,10A-Tetrahydro-5,9-Dimethyl-10,1A-(Epoxymethano)-2H-Oxireno[4,5]Cyclodeca[1,2-B]Furan-12-One
CAS No.	20149-39-7
Molecular Formula	C17H20O6
Molecular Weight	320.34 g/mol
Synonyms	6-Acetoxy-3,6,10,10a-tetrahydro-5,9-dimethyl-10,1a-(epoxymethano)-2H-oxireno[4,5]cyclodeca[1,2-b]furan-12-one; Parthenolide 6-acetate; Parthenolide acetate derivative; Sesquiterpene lactone acetate; 1a,4-Epoxy-6β-acetoxymethyl-10β-methyl-7-oxatricyclo[4.3.1.1²,⁵]undec-3-en-9-one (related structural name); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (1As,4E,6R,10S,10Ar)-6-Acetoxy-3,6,10,10A-Tetrahydro-5,9-Dimethyl-10,1A-(Epoxymethano)-2H-Oxireno[4,5]Cyclodeca[1,2-B]Furan-12-One is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.