Description

n-Trifluoroacetylproline Anhydride is a specialized fluorinated proline derivative, serving as a crucial chiral building block and protecting group reagent in advanced organic synthesis. Its value lies in enabling the efficient synthesis of complex, high-value molecules, particularly in the pharmaceutical sector where precise stereochemistry is paramount. This compound is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and advanced material science who require high-purity, reliable intermediates for peptide mimetics and active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of peptide-based drugs and protease inhibitors.
• Chiral Auxiliary & Protecting Group: Used in asymmetric synthesis to control stereochemistry, particularly for proline residues.
• Agrochemical Research: Intermediate in the development of novel, fluorinated active ingredients with enhanced properties.
• Peptide Mimetic Design: Facilitates the creation of conformationally restricted peptide analogs for drug discovery.
• Bioconjugation Chemistry: Useful for modifying biomolecules by introducing the stable trifluoroacetyl group.
• Academic & Process R&D: Employed in methodological development and scale-up studies for complex organic molecules.

Basic Information

Product Name	n-Trifluoroacetylproline Anhydride
CAS No.	2966-05-4
Molecular Formula	C7H6F3NO3
Molecular Weight	209.12 g/mol
Synonyms	N-(Trifluoroacetyl)proline Anhydride; 1-(Trifluoroacetyl)-L-proline Anhydride; L-Proline, 1-[(trifluoroacetyl)]-, anhydride; 2-Pyrrolidinecarboxylic acid, 1-(trifluoroacetyl)-, anhydride; Trifluoroacetylproline cyclic anhydride; N-TFA-Proline Anhydride; TFA-Pro-OH Anhydride; Proline, N-trifluoroacetyl-, anhydride
EINECS	Contact for details

Quality Control

Our n-Trifluoroacetylproline Anhydride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and impurity profile analysis by HPLC, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.