Description

Diethyl 4-Fluorophenyl Malonate is a high-purity fluorinated malonate ester, a versatile and critical building block in advanced organic synthesis. Its value lies in its reactive diester and fluorinated aromatic structure, enabling precise molecular construction for complex target compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors, particularly for developing active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, including potential CNS agents and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic components in electronic display materials.
• Advanced Polymer Modification: Incorporated to introduce fluorinated phenyl groups into polymer backbones, altering physical and chemical properties.
• Organic Synthesis Reagent: Employed in Knoevenagel condensations and other C-C bond-forming reactions to create complex, fluorinated molecular architectures.
• Fluorine Chemistry Research: A valuable standard and starting material for academic and industrial research exploring new fluorination methodologies and SAR studies.

Basic Information

Item	Detail
Product Name	Diethyl 4-Fluorophenyl Malonate
CAS No.	2965-90-4
Molecular Formula	C₁₃H₁₅FO₄
Molecular Weight	254.26 g/mol
Synonyms	Diethyl (4-fluorophenyl)propanedioate; 4-Fluorophenylmalonic Acid Diethyl Ester; Diethyl 4-Fluorobenzylmalonate; Propanedioic acid, (4-fluorophenyl)-, diethyl ester; Diethyl (4-fluorophenyl)malonate; Ethyl 4-fluorophenylmalonate; (4-Fluorophenyl)malonic acid diethyl ester; Diethyl p-fluorophenylmalonate
EINECS	220-980-7

Quality Control

Our Diethyl 4-Fluorophenyl Malonate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.