Description

2'-Fluorothymidine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and diagnostic research. Its primary value lies in its role as a precursor for positron emission tomography (PET) imaging agents, particularly for monitoring cellular proliferation in oncology. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and radiopharmaceutical sectors. It serves as a critical intermediate in the synthesis of advanced tracers used to assess tumor growth and treatment efficacy in clinical and preclinical settings.

Application

• PET Tracer Synthesis: Primary precursor for the production of [18F]FLT, a vital radiopharmaceutical for imaging tumor cell proliferation.
• Oncology Research: Used in the development and study of novel anti-cancer agents and diagnostic tools targeting DNA synthesis.
• Medicinal Chemistry: Serves as a versatile building block for synthesizing fluorinated nucleoside analogs with potential therapeutic activity.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies related to thymidine kinase and DNA replication pathways.
• Radiopharmaceutical Manufacturing: A critical starting material in GMP-compliant production processes for certified imaging agents.
• Academic & Institutional Research: Used in universities and research institutes for fundamental studies in molecular biology and diagnostic imaging.

Basic Information

Product Name	2'-Fluorothymidine
CAS No.	2923-73-1
Molecular Formula	C10H13FN2O5
Molecular Weight	260.22 g/mol
Synonyms	1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)thymine; 2'-Deoxy-2'-fluorothymidine; FLT; Alovudine; FMAU; 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 2'-Fluoro-5-methyluridine; 2'-F-ara-T
EINECS	220-879-9

Quality Control

Our 2'-Fluorothymidine is manufactured under strict quality systems to ensure high purity and consistency for sensitive research and production applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support its use in advanced pharmaceutical development. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.